P. Mishra, A. Middha, V. Saxena
Jun 1, 2016
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Abstract
A prolonged increase in pro-inflammatory cytokines, TNF-α and IL-6 occurs in inflammatory diseases. Although cinnoline belongs to a family of fairly well known heterocycles, the interest in the study of its derivatives continues. Cinnoline compounds demonstrate interesting bioactivity and many research papers have discussed the biological property, structureactivity relationship, and applications in medicinal science. A new series of substituted Cinnoline derivatives condensed with Thiophene moieties (12a-j) were synthesized and their anti-inflammatory was evaluated. The anti-inflammatory activity was assessed by rat paw edema method. The pharmacological screening showed that many of these obtained compounds have significant anti-inflammatory activity, comparable to the standard drug (phenylbutazone). The compound 12DSDi produces maximum anti-inflammatory activity compared to other tested compound.