Xian-Long Wang, Lin-Ling Gan, Cheng‐He Zhou
Mar 1, 2011
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Abstract
The novel diphenyl piperazine-based sulfanilamides were conveniently and efficiently synthesized via multi-step reactions starting from commercially available acetanilide and (4-chlorophenyl)(phenyl)methanone. The synthesized title compounds and their intermediates were characterized by 1H NMR, 13C NMR, IR and MS spectra as well as elemental analyses and screened in vitro for their antibacterial and antifungal activities. The antimicrobial activity showed that the target compounds 14 and 16 exhibited better inhibitory potency than sulfanilamide against all tested bacterial strains.