Pratibha Sharma, N. Rane, P. Pandey
Oct 1, 2006
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0
Influential Citations
18
Citations
Quality indicators
Journal
Archiv der Pharmazie
Abstract
A number of novel pyrimido[4,5‐d]pyrimidine‐2,7‐dithone derivatives bearing hydrazino and N‐benzylidinehydrazino substitution were efficiently synthesized and screened for in vitro antibacterial activities against the representative panel of three Gram‐positive and two Gram‐negative bacteria. All the synthesized compounds showed the potent inhibitory action against Gram‐positive bacteria. Particularly, N‐benzylidinehydrazino‐substituted compounds imparted profound effect. Furthermore, the Connolly‐accessible surface area values were also calculated for the target compounds and correlated with the expressed biological activity.