A. Pyrih, Michael Berninger, A. Gzella
Jun 18, 2018
Citations
1
Influential Citations
4
Citations
Journal
Synthetic Communications
Abstract
Abstract The synthesis of thiosemicarbazide of 1-butyl-6-fluoro-7-morpholino-4-oxo-1,4-dihydroquinoline-3-carboxylic acid as well as its heterocyclic derivatives – 1,3,4-thiadiazole and 1,2,4-triazole are described; the modification of proper 1,2,4-triazole derivative by maleimides is also presented. Spectral properties of the prepared compounds and X-ray analysis for the selected compounds were studied. For the compounds antitrypanosomal potential and the toxicity were determined. Graphical Abstract