M. Maste, P. Jeyarani, M. Kalekar
Jul 28, 2011
Citations
0
Influential Citations
2
Citations
Journal
Asian Journal of Research in Chemistry
Abstract
The present research work was aimed to synthesize some benzimidazole acetic acid derivatives and also the derivatives associated with 1,2,4 triazolone and was investigated for their biological activities. A two different series of compounds were synthesized, 4-[(2-aryl methyl-1H-benzimidazol-1-yl) acetyl] 5 nitro-2,4 –dihydro-3H-1,2,4 triazol3-one and 4-[(2-aryl methyl-1H-benzimidazol-1-yl)methyl] 5 nitro-2,4-dihydro-3H-1,2,4 triazol-3-one. The newly synthesized compounds have been characterized by their analytical and spectral (IR and 1H NMR, C13 NMR, mass spectra) properties. All the compounds have been screened for their anti tubercular and antimicrobial activities by standard methods. Results of activities reveal that compound shown promising anti tubercular activity at both the concentration compared to standard drug streptomycin, and shown good antimicrobial activities.