G. Caliendo, G. Greco, P. Grieco
1996
Citations
2
Influential Citations
16
Citations
Journal
European Journal of Medicinal Chemistry
Abstract
Summary A set of N -[2-(alkylamino)ethyl]benzotriazol- X -yl isobutyramides have been synthesized and assayed in vivo for their local anesthetic activity and acute toxicity. Some of them showed a more favorable pharmacological profile than that of the reference drug lidocaine. QSAR studies have delineated the influence of overall lipophilicity on surface and infiltration anesthetic activities.