Li Zi-cheng
2013
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Quality indicators
Journal
Chemical Research and Application
Abstract
A new series of 5-[(1H-indol-3-yl)methylene]thiazolidine-2,4-dione derivatives(e1-e9)were synthesized by incorporating different N-substituted-1H-indole into thiazolidine-2,4-dione with methylene bond,and further modified at the nitrogen of thiazolidine-2,4-dione by different groups.Their structures were determined by IR,1H NMR and HRMS.Their antitumor activity was evaluated over five cancer cells by the MTT assay.All the target compounds displayed antitumor activity against A549,HCT116 and PC-9,and those with benzyl at 1-position of indole(e1 and e3)had similar anticancer activity as 5-Fluorouracil(5-FU)over the test cancer cells(exception of A375),and had higher activity against A549 and HCT116(IC50 value lower than 30 μM),providing a good lead for subsequent optimization as cancer inhibitory agents.