F. Hosono, S. Nishiyama, S. Yamamura
Sep 8, 1994
Citations
0
Influential Citations
8
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract The enantiospecific synthesis of [(2′S, 3′S)-bis(hydroxymethyl)azetidin-1-yl]pyrimidine nucleosides 15, 18, and 20, the first members of a new class of nucleoside analogs in which the oxetane ring in oxetanocin-A 1 is replaced by an azeitidine ring linked to a nucleic base through an NN bond, was achieved via construction of the base on the 1-aminoazetidine 11 prepared from (+)-dieethyl- l -tartrate. None of these compounds had significant antiviral activity in cell culture tests.