C. Karthikeyan, V. Solomon, Hoyun Lee
May 1, 2017
Citations
1
Influential Citations
21
Citations
Quality indicators
Journal
Arabian Journal of Chemistry
Abstract
A series of novel substituted 2-(phenyl)-3H-benzo(d)imidazole-5-carboxylic acids (1a-1j) and its methyl esters (2a-2f) were synthesized and examined for their antiproliferative effects against three breast cancer cell lines (MDA-MB231, MDA-MB468 and MCF7) in vitro. Most of the compounds exhibited comparable or greater antiproliferative effects than the reference com- pound cisplatin. Compound 2e bearing 5-fluoro-2-hydroxyphenyl substituent was found to be the most active derivative of the series with GI50 values of 6.23, 4.09 and 0.18 lM against MDA- MB468, MDA-MB231 and MCF7 breast cancer cell lines, respectively. Our findings described here exemplify the usefulness of the title compounds as a lead for the development of more effective can- cer therapeutics for the treatment of breast cancer. a 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University.