Xuanqi Liu, Ya-Qin Liu, X. Shao
2016
Citations
0
Influential Citations
10
Citations
Journal
Chinese Chemical Letters
Abstract
Abstract A series of novel tetrahydroimidazo[1,2-a]pyridine-5(1H)-one derivatives containing a electronegative pharmacophore ( CNO2) were synthesized via practical aza-ene reaction and characterized by 1H NMR, 13C NMR, 19F NMR and HRMS. Preliminary bioassays showed that some of the target compounds exhibited good insecticidal activity against brown planthopper (Nilaparvata lugens) and cowpea aphids (Aphis craccivora) at 500 mg L−1. Among them, compound 11h was active against brown planthopper at 100 mg L−1. The insecticidal activities varied significantly depending on the types and patterns of the substituents, which provided guidance for further investigation on structure modifications.