M. Noolvi, H. Patel, S. Kamboj
Nov 1, 2016
Citations
0
Influential Citations
26
Citations
Journal
Arabian Journal of Chemistry
Abstract
Abstract A series of 1,3,4-thiadiazole derivatives of 2-(4-formyl-2-methoxyphenoxy) acetic acid ( 6a – s ) were synthesized by cyclization of carboxylic acid group of 2-(2-methoxy-4-(3-oxo-3-substituted phenylprop-1-enyl)phenoxy) acetic acid ( 4a – s ) with thiosemicarbazide in the presence of POCl 3 or PPA. The structures of the compounds were confirmed by IR, 1 H NMR and mass analysis. All the compounds have been evaluated in vitro for their antimicrobial activities against several strains of microbes and show significant activity.