Bowen Ke, Yong Qin, F. Zhao
Sep 1, 2008
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Influential Citations
11
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
Novel 3'-N-tert-butylsulfonyl analogues 10a-c of docetaxel were synthesized and their biological evaluation in cytotoxicity in vitro against several human tumor cell lines were presented. The biologically tested results showed that N-oxide pyridyl substituted10b-c had potent cytotoxicities against human tumor cell lines Eca-109, SKOV3, SMMC-7721, HCT-8, PC3, MCF-7, HeLa and KB.