N. Naik, H. V. Kumar, H. Swetha
Jul 2, 2010
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0
Influential Citations
7
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Journal
Bulgarian Chemical Communications
Abstract
A series of carbazole conjugated with different aminophenols and substituted aminophenols were synthesized by base catalyzed condensation reaction. The key intermediate 1-(9H-carbazol-9-yl)-2-chloroethanone, was obtained by N-acylation of carbazole with chloroacetyl chloride. The newly synthesized compounds were characterized by spectral and elemental analysis data and studied for their radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Butylated hydroxy anisole (BHA) was used as a reference antioxidant compound and the comparative study with newly synthesized compounds was also done. Among the analogues, 1-(9H-carbazole-9-yl)-2-(4-hydroxy-3-methoxy-phenylamino)ethanone, bearing electron donating methoxy substituent in the phenolic moiety, showed predominant activity.