K. Battula, S. Narsimha, V. Nagavelli
Apr 10, 2016
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0
Influential Citations
19
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Journal
Journal of The Serbian Chemical Society
Abstract
A convenient synthesis of novel 1,4-disubstituted 1,2,3-triazoles ( 4a – j and 5a – j ) is reported via copper(I)-catalyzed one pot [3+2] cycloaddition of various alkyl halides, sodium azide with 4-(prop-2-yn-1-yl)thiomorpholine and 4-(prop-2-yn-1-yl)thiomorpholine 1,1-dioxide. All the synthesized compounds were investigated for their antimicrobial activity. Compounds 4a , 4b , 4c , 4g , 5a and 5j against Staphylococcus epidermidis , 4a, 5a and 5d against Pseudomonas aeruginosa, 4a , 4b and 4g against Klebsiella pneumoniae , 4b , 5a and 5d against S. aureus and 5b , 5e and 5j against Bacillus subtilis showed excellent antibacterial activity compared to the standard drugs penicillin and streptomycin. Compounds 4c, 4e , 4f , 4j , 5c , 5d , 5g and 5j registered moderate antifungal activity as compared with the standard drug amphotericin B.