V. Reddy, K. R. Reddy
Oct 1, 2010
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0
Influential Citations
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Citations
Journal
Chinese Chemical Letters
Abstract
Abstract The synthesis of a new series of 3-(5-substituted benzimidazol-2-yl)-5-arylisoxazolines ( 6a – h ) was achieved in excellent yields by the condensation of 1-(1 H -benzimidazol-2-yl)-3-(substituted phenyl)prop-2-en-1-ones ( 5a – h ) with hydroxylamine at room temperature. These 1-(1 H -benzimidazol-2-yl)-3-(substituted phenyl)prop-2-en-1-ones ( 5a – h ) were obtained by the condensation of 2-acetyl benzimidazoles ( 4a – d ) with different aromatic aldehydes, which in turn were obtained by the oxidation of 2-(α-hydroxy)ethyl benzimidazoles ( 3a – d ) prepared by the reaction of o -phenylenediamines ( 1a – d ) with α-hydroxy propionic acid 2 . The synthesized compounds were characterized by their IR, 1 H NMR and MS analyses. These compounds were screened for their antibacterial and antifungal activity by standard methods and found some of them active.