Yanyan Sun, Gang Xu, Zhe Cao
Jan 30, 2013
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
Inorganica Chimica Acta
Abstract
Abstract Five platinum(II) complexes with N-monoalkyl derivatives of 1 R ,2 R -diaminocyclohexane as ligands and D-(+)-camphorate anion as leaving group have been synthesized and characterized by elemental analysis, IR, 1 H NMR, ESI-MS, and HRMS spectra. All complexes were evaluated for their in vitro cytotoxicity against four human tumor cell lines and most of them showed promising cytotoxic activity, especially compounds 3 and 4 with branched alkyl substituent at one of nitrogen atoms. Preliminary mechanism study by flow cytometry and agarose gel electrophoresis was also carried out in comparison with cisplatin and oxaliplatin.