Warren B. Shapiro, Martin F. Tansy, Samuel Elkin
Oct 1, 1968
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
Journal of pharmaceutical sciences
Abstract
7,10-Ethano-1-thia-4,7-diazaspiro [4.5] decane dihydrochloride was prepared by the condensation of 3-quinuclidone hydrochloride with 2-aminoethanethiol hydrochloride. The compound was shown to have potential radioprotective properties against a lethal dose of X-radiation in mice. Optimum protection was obtained in a group of mice pretreated intraperitoneally with 0.20 mg./g. of 7,10-ethano-1-thia-4,7-diazaspiro [4.5] decane dihydrochloride 15 min. prior to exposure, where 58.3 percent survived. A toxicity study showed the i.p. LD50 of the compound to be 295 mg./kg. with a dose range of 257–339 mg./kg. (p < 0.05).