S. Sirakanyan, D. Spinelli, A. Geronikaki
Jan 1, 2021
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Chemistry of Heterocyclic Compounds
Abstract
The synthesis of new cyclopenta[4',5']pyrido[3',2':4,5]furo[3,2- d ]pyrimidin-7-amines have been carried out to study their antimicrobial activity. The biological tests evidenced that some of the synthesized compounds exhibit pronounced antimicrobial properties. A study of the structure–activity relationship revealed that the 3,5-dimethyl-1 H -pyrazol-1-yl moiety linked to the carbon C-9 of the pyrimidine plays a decisive role in the manifestation of activity. The influence of 3,5-dimethyl-1 H -pyrazol-1-yl group on the Dimroth rearrangement and azide-tetrazole equilibrium has also been examined.