N. Xi, Yunxin Y Bo, E. Doherty
Dec 1, 2005
Citations
0
Influential Citations
25
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
A thiazole derivative, 2-(2,6-dichlorobenzyl)-N-(4-isopropylphenyl) thiazole-4-carboxamide (1), was identified as a TRPV1 antagonist. We synthesized various thiazole analogs and evaluated them for their ability to block capsaicin- or acid-induced calcium influx in TRPV1-expressing CHO cells. The IC(50) values of the most potent antagonists were ca. 0.050microM in these assays.