M. Hamann, C. Pierra, J. Sommadossi
Mar 15, 2009
Citations
0
Influential Citations
5
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry
Abstract
Several thieno[3,4-d]pyrimidine derivatives, including four hitherto unknown 2',3'-dideoxy- and 2',3'-dideoxy-2',3'-didehydro-C-nucleoside analogues of adenosine and inosine have been synthesized. When evaluated in cell culture experiments against human immunodeficiency virus, none of the tested compounds exhibited any significant antiviral effect, while two of them showed some cytotoxicity.