M. El-Sherbeny, M. El-Ashmawy, H. El-Subbagh
1995
Citations
1
Influential Citations
61
Citations
Journal
European Journal of Medicinal Chemistry
Abstract
Summary A series of 2-substituted amino-3-aminocyclopenteno or cyclohexeno[ b ]thieno[2,3- d ]-3,4-dihydropyrimidin-4-ones has been synthesized by reacting the corresponding thioureido derivatives with hydrazine hydrate. The thienoprimidine analogues obtained were further used to prepare their arylideneamino, thienotriazolopyrimidine or 2-methylthienotriazolopyrimidine derivatives. The prepared compounds were screened for antimicrobial, antiviral and cytotoxic activity. Some of the tested compounds showed promising activity. Detailed syntheses and spectroscopic and biological data are reported.