Synthesis and evaluation of tumor cell growth inhibition of methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates. Structure-activity relationships, effects on the cell cycle and apoptosis.
Key Takeaway: Methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates (IIIc-IIIe) show potential in inhibiting tumor cell growth by causing apoptosis in the NCI-
Abstract
The most active compounds in terms of apoptosis in the NCI-H460 cell line are (IIIc)—(IIIe).