Naoto Uramaru, En-Chiuan Chang, Wan-Ping Yen
Dec 26, 2014
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Influential Citations
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Quality indicators
Journal
Arabian Journal of Chemistry
Abstract
Abstract New polysubstituted N -arylpyrazole derivatives were synthesized from N 1-arylsydnone with acetylene and boronic acid, including 2-thiophenyl, 3-thiophenyl, 2-benzo[ b ]thiophenyl, or dibenzothiophenyl-4-boronic acid, via 1,3-dipolar cycloaddition and Suzuki coupling reaction. Based on the growth inhibitory activity results against lung carcinoma (NCI-H226), nasopharyngeal (NPC-TW01), and T-cell leukemia (Jurkat) cancer cells, compounds 5d and 7d with dibenzothiophenyl bioisostere possessed the significant inhibitory activity for NPC-TW01 (32 μM and 16 μM) and NCI-H226 (16 μM and 8.9 μM), respectively.