L. Clary, C. Santaella, P. Vierling
Nov 20, 1995
Citations
0
Influential Citations
18
Citations
Quality indicators
Journal
Tetrahedron
Abstract
Abstract The syntheses of various fluorocarbon/fluorocarbon and fluorocarbon/hydrocarbon amido-connected phosphocholines derived from diaminopropanols and serine are described. They were best obtained by phosphorylation of suitable alcohol precursors using 2-chloro-2-oxo-1,3,2-dioxaphospholane and subsequent ring opening with trimethylamine. The di-alkylamidopropanols were prepared by acylation, using perfluoroalkylated acid chlorides, of 1,3-diamino-2-propanol or of 2,3-diamino-1-propionic methylester followed by reduction of the ester bond. The perfluoroalkylated N-alkanoyl-serine alkylamides were prepared by condensation of Boc-O-Bn-L-serine with an aliphatic or perfluoroalkylated amine, Boc-deprotection, acylation and then hydrogenolysis for benzyldeprotection. Acute toxicity evaluations indicate a very promising in vivo tolerance for these series of amido-linked compounds.