Alex Bubar, P. Estey, M. Lawson
Jan 23, 2012
Citations
0
Influential Citations
30
Citations
Journal
The Journal of organic chemistry
Abstract
The synthesis and characterization of extended, conjugated molecules containing isoindolinone units was explored. Nucleophilic cyclizations between an amide and an alkyne were found to be an efficient method of producing the desired isoindolin-1-ones in high yields. A variety of derivatives were synthesized, demonstrating that a number of structural alterations could be made while maintaining good regio- and stereospecificity in the cyclized product.