Hassan Vasheghani Farahani, M. Bayat, Shima Nasri
Feb 20, 2019
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0
Influential Citations
5
Citations
Journal
Silicon
Abstract
A novel series of 2-amino-3-(2-oxothiazol-methyl)-substituted-1,4-naphthoquinone compounds were designed and prepared, by the three-component one-pot reaction of 2-aminothiazole, 2-hydroxy-1-4-naphthoquinone and aromatic aldehydes using of nano-SiO 2 (20% mol) as an efficient Lewis acid and heterogeneous nano-catalyst in acetonitrile at room temperature in the period of time 2–5 h. Silica-based materials used for developing an environmental friendly methodology for the preparation of potential biologically active molecular scaffolds. The direction of product formation and the structure of all the synthesized compounds were identified by spectroscopic methods. The remarkable superiorities of this procedure include good yields (70–89%), use of an inexpensive and commercially available catalyst, regioselectivity and simple work-up.