L. Fei
2012
Citations
0
Influential Citations
0
Citations
Journal
Acta Universitatis Medicinalis Nanjing
Abstract
Objective:To synthesize the uncoupler 2-[(1H-benzo[d]triazol-5-ylamino) methyl]-4,6-dichlorophenol for neuronal nitric oxide synthase(nNOS) with postsynaptic density protein-95(PSD-95).Methods: 5-amine-1H-benzo[d]triazol was firstly synthesized from 4-nitrobenzene-1,2-diamine by diazotization and reduction.Then the target compound was obtained by reduction after condensation of 5-amine-1H-benzo [d]triazol and 3,5-dichloro-2-hydroxybenzaldehyde.Rusults: The target compound was confirmed by hydrogen nuclear magnetic resonance spectra(1H-NMR) and carbon nuclear magnetic resonance spectra(13C-NMR),and the overall yield is 20.3%.Conclusion: The program of experiments can be used to synthesize 2-[(1H-benzo[d]triazol-5-ylamino) methyl]-4,6-dichlorophenol quickly and easily.