Yan Feng-mei, Liu He-qin
2009
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Journal
Chinese Journal of Pharmaceuticals
Abstract
N-(4-Chloro-3-trifluoromethylphenyl)-N′-(4-bromophenyl)urea,a key intermediate of antitumor agent sorafenib was synthesized from 4-chloro-3-trifluoromethylaniline and triphosgene to give 4-chloro-3- trifluoromethyl phenyl isocyanate,which without seperation reacted with 4-bromoaniline in about 75%overall yield and 99.8%purity.