Li Ga
2014
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Journal
Guangzhou Chemical Industry
Abstract
TEBA was used as phase-transfer catalyst to synthesize Fenofibrate acid from 4-hydroxy-4'-chlorobenzophenone and chloroform in water solution of potassium hydroxide with acetone as solvent. The effects of factors such as the concentration of water solution of potassium hydroxide,the catalyst of TEBA,the reaction temperature and the catalyst of chloroform on the yield were examined. The optimal reaction conditions determined were that 4-hydroxy-4'-chlorobenzophenone catalyst was 30 g,acetone catalyst was 120 g,chloroform catalyst was 40 g,TEBA catalyst was2. 5 g,the concentration of water solution of potassium hydroxide was 50%,reaction temperature was 30 ℃,and the yield reached 89. 7%.