Xu Shaohong, Zhang Wei
2011
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Journal
Chemical Reagents
Abstract
Fiacitabine was synthesized from cytidine by protection with Ac2O and selective deprotection with hydrazine hydrate to give 3′,5′-二-O-acetyl-β-D-furanosylcytidine,which was subjected to reaction with diethylaminosulfur trifluoride,deprotection with NH3-CH3OH and then iodination under microwave irradiation with an overall yield of about 42.3%.The structure of product was confirmed by 1HNMR and 13CNMR.