Liu Jian-fen
2014
Citations
0
Influential Citations
1
Citations
Journal
Journal of Pharmaceutical Research
Abstract
Objective To synthesize fingolimod.Methods Fingolimod was synthesized with 2-phenethyl alcohol and sodium bromide as starting material,and through a series of reactions,such as substitution,acylation,condensation etc.Results The struture of target compound was confirmed by1H-NMR and MS.The overall yield of the process was26.9 %.Compared with the reported method,the overall yield was 6.4% higher.Conclusion This synthetic process was convenient,and had high yield,low cost,and mild reaction condition.It was suitable for industrial production by its operation,low cost and.