Min‐Tsang Hsieh, Hui-Chang Lin, S. Kuo
Sep 29, 2016
Citations
0
Influential Citations
10
Citations
Journal
Tetrahedron
Abstract
Abstract Starting from commercially available 2-chloro-4-fluorobenzoic acid 4, synthesis of fluazolate was achieved in up to 30% overall yield via the key procedure of either regioselective [3+2] cyclocondensation of trifluoromethyl-α,β-ynone 2 with hydrazine hydrate or nucleophilic substitution-cyclization of trifluoromethyl-α,β-dibromoenone 10 with hydrazine hydrate.