R. Sarfati, T. Berthod, C. Guerreiro
1995
Citations
0
Influential Citations
6
Citations
Journal
Journal of The Chemical Society-perkin Transactions 1
Abstract
Treatment, of 5′-O-dimethoxytritylthymidine 1 and of 4-N-benzyloxycarbonyl-2′-deoxy-5′-O-dimethoxy-trityl-cytidine 12 with a mixture of 6-(benzyloxycarbonylamino)hexanoic acid, dicyclohexylcarbodiimide and 4-(dimethylamino)pyridine yielded 3′-O-acylated derivatives 2 and 13. These were further converted into 3′-O-(6-aminohexanoyl)thymidine 7 and 3′-O-(6-aminohexanoyl)-2′-deoxycytidine 16 monophosphates. The latter compounds were labelled at the aliphatic amino group with fluorescent probes and transformed into their triphosphates 9 and 18.