M. Kasuya, Ayaka Ito, K. Hatanaka
May 1, 2007
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0
Influential Citations
14
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract A series of fluorinated galactosides, dodecyl 2-deoxy-2-fluoro-β- d -galactopyranoside (2F Gal), dodecyl 4-deoxy-4-fluoro-β- d -galactopyranoside (4F Gal) and dodecyl 6-deoxy-6-fluoro-β- d -galactopyranoside (6F Gal), was chemically synthesized and introduced to B16 cells to serve as scaffolds for cellular enzyme glycosylation. Results showed that the presence of fluorine exercised significant effects on cell viability. Among the fluorinated galactosides used, 2F Gal was glycosylated to afford a GM4 analogue.