Elias Babarbi, M. Haffas, M. Guerri
Nov 26, 2015
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Journal
Biomedical and Pharmacology Journal
Abstract
Tris (pentafluorophenyl) phosphine, bis (pentafuorophenyl) phenylphosphine, tris (4fluorophenyl) phosphine and triphenylphosphine are readily reacted with an excess of methyl iodide in chloroform at boiling point to afford respectively phosphonium salts of methyl tris (pentafluorophenyl)phosphonium iodide, methyl bis (pentafuorophenyl)phenylphosphonium iodide, methyl tris (4-fluorophenyl) phosphonium iodide and methyl triphenylphosphonium iodide. These phosphonium salts showed significant activity against all the bacteria tested, Escherichia Coli, Protius, Staphylococcus Aureus and Pseudomonas. The combination of these phosphonium salts with the penicillin G or V gives a synergistic effect.