V. Iaroshenko, D. Sevenard, A. Kotljarov
Feb 11, 2009
Citations
0
Influential Citations
37
Citations
Journal
Synthesis
Abstract
Starting from 5-amino-1-(2,3-O-isopropylidene-b-D-ri- bofuranosyl)-1H-pyrazole, fluorine-containing 1,3-CCC-, 1,3-CNC- dielectrophiles and 2,4,6-tris(trifluoromethyl)-1,3,5-triazine, a set of fluorinated pyrazolo(3,4-b)pyridine and pyrazolo(3,4-d)pyrimi- dine nucleosides was obtained. Synthetic access to stable 4-(poly- fluoroalkyl)-4,7-dihydro-1H-pyrazolo(3,4-b)pyridin-4-ole was elaborated, which can be considered to be mimetics of the putative transition state involved in adenosine deaminase activity.