K. Hiramatsu, Takashi Honjo, V. Rauniyar
Jan 4, 2016
Citations
0
Influential Citations
33
Citations
Journal
ACS catalysis
Abstract
Stereoselective synthesis of two fluorine-bearing drug-like scaffolds, dihydroquinazolone and benzooxazinone, has been accomplished through asymmetric fluorocyclization reactions initiated by the fluorination process. The reaction employs double axially chiral anionic phase-transfer catalysts to achieve high diastereo- and enantioselectivities, and a wide range of fluorine-containing dihydroquinazolones were obtained (>20:1 dr, up to 98% ee).