Li Pei-w
2015
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Guangzhou Chemical Industry
Abstract
Started from 5- Bromonicotinic acid,5-( 4- fluorophenyl)- 3- chloromethyl pyridine was synthesized by employing five steps of reaction with esterification,Suzuki coupling,sodium tetrahydroborate reduction and chlorination.Structure of products was characterized by1H- NMR. Compared with reported methods,this route suppressed side reactions,simplified reaction and isolation process,and increased yield and purity. It was suitable for industrialized production.