E. Pfund, T. Lequeux
Aug 3, 2017
Citations
0
Influential Citations
9
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Journal
Synthesis
Abstract
Abstract Pyrrolidines and their derivatives are of great interest in medicinal chemistry and organic synthesis. Fluoropyrrolidines and (fluoroalkyl)pyrrolidines have been utilized in the preparation of medicinal drugs and also as organocatalysts. The synthesis of such compounds is achieved through the fluorination of pyrrolidine derivatives or by multistep synthesis from already containing fluoroalkyl precursors. 1 Introduction 1.1 General Interest of Fluorine-Containing Pyrrolidines 1.2 Fluoroalkylpyrrolidines and the Gauche Effect 2 Fluoropyrrolidines 2.1 3-Fluoropyrrolidines 2.2 3,3- and 3,4-Difluoropyrrolidines 2.3 3,3,4-Trifluoropyrrolidines 2.4 3,3,4,4-Tetrafluoropyrrolidines 3 (Difluoromethyl)- and (Trifluoromethyl)pyrrolidines 3.1 2-(Trifluoromethyl)pyrrolidines 3.2 3- and 4-(Trifluoromethyl)pyrrolidines 3.3 2-(Difluoromethyl)pyrrolidines 3.4 3- and 4-(Difluoromethyl)pyrrolidines 4 (Monofluoroalkyl)pyrrolidines 4.1 2-(Monofluoromethyl)pyrrolidines 4.2 2-(Monofluoroalkyl)pyrrolidines 4.3 2-(Monofluoroalkenyl)pyrrolidines 5 Conclusion