Liu Dong-zhi
2008
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Journal
Chemical Industry and Engineering
Abstract
Fluoxetine hydrochloride is a potent and highly selective inhibitor of neutral serotonin-reuptake and is one of the most important drugs for the treatment of psychiatric disorders and metabolic problems.Due to its market value and the different pharmacological activities displayed by analogues of fluoxetine, several synthetic methods,including the enantioselective synthesis of both enantiomers,have been reported.Progress in enantioselective synthetic methods of fluoxetine hydrochloride were reviewed in this paper.