Zhou Xue-qin
2008
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
Fluoxetine hydrochloride(4) in overall yield of 41.0% was synthesized by a four-step reaction in which acetophenone reacted with methylamine hydrochloride and paraformaldehyde to obtain 3-methylaminopropiophenone hydrochloride(1);then 1 was reduced by potassium borohydride in methanol to prepare 3-methylamino-1-phenylpropanol(2);finally,2 reacted with 4-chlorobenzo-trifluoride and formed salt.The structrue of 4 was characterized by 1H NMR and MS.