Li Zi-yuan
2007
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Journal
West China Journal of Pharmaceutical Sciences
Abstract
OBJECTIVE To synthesize Fluticasone propionate.METHODS Fluticasone propionate was synthesized from Flumethasone(2) by H5IO6 Oxidation,Propionyl chloride acylation,and then reacted with N,N-dimethylthiocarbamoyl chloride to get 5,5 reacted with BrCH2Cl,and at last,using KF replace chloride with fluorine to get target product.RESULTS Chemical structure of Fluticasone propionate and its intermediate were confirmed by MS and 1HNMR,total yield 47.8%.CONCLUSION The method improved could avoid the usage of BrCH2F which was expensive and would destroy to the ozonosphere.The yield is corresponded to the method reported.