L. Yi
2010
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Journal
Chemical Reagents
Abstract
Flutrimazole,an antifungal agent,was synthesized from 2-fluorobenzophenone and p-fluorobromobenzene,via the Grignard reaction,halogenation and N-alkylation in an overall yield of 65.8%(based on 2-fluorobenzophenone) with a product purity of over 99.7%.The synthetic procedure was optimized.The halogenation reaction with acetyl chloride and the N-alkylation reaction under microwave irradiation were explored.The structure of the title compound was confirmed by melting point measurement,elemental analysis,IR and 1HNMR.The improved synthetic route was convenient and effective,and the yield and purity of the title product were all improved.