Luc Demange, A. Ménez, C. Dugave
Mar 5, 1998
Citations
0
Influential Citations
55
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Boc- cis -4-fluoro-L-proline and 4-difluoro-L-proline, usable in classical peptide synthesis, were obtained in respectively 71% (3 steps) and 65% (4 steps) overall yields from the readily available trans -4-hydroxy-L-proline methyl ester. The corresponding fluorinated trans -isomer was isolated in 24% yield (5 steps). Transformation of Boc-protected compounds to their Fmoc-equivalents was performed in high yields.