S. Nzikayel, Akpan Ij, A. Ec
2018
Citations
0
Influential Citations
2
Citations
Journal
Medicinal Chemistry
Abstract
Acethydrazide was modified by addition of benzaldehyde refluxing in ethanol to obtain a new product: N’-Benzylideneacethydrazide. The new product obtained was complexed with Iron (II) and Copper (II) salt. The result of the FT-IR analysis of acethydrazide, N’-Benzylideneacethydrazide and its complexes were compared to ascertain the possible points and mode of coordination to the metal (II) centre. The shift in the absorption band of the N’-Benzylideneacethydrazide (N'-BA) from 3337 cm-1 (N-H) to 3462 cm-1 and 3406 cm-1 (N-H) in the spectra of the Fe(II) and Cu(II) complexes respectively, indicates the coordination of the N’-Benzylideneacethydrazide to the metal ion via O and N atoms of the carbonyl and amide functional groups. The products were further characterized by UV/Visible spectroscopic technique and other physical measurements like melting point and solubility test.