M. A. Wijdeven, F. L. Delft, F. Rutjes
Jul 24, 2010
Citations
0
Influential Citations
13
Citations
Journal
Tetrahedron
Abstract
The synthetic versatility of three chemoenzymatically prepared hydroxypiperidine building blocks has been explored, resulting in a library of enantiopure functionalized piperidines. Key steps involved N-acyliminium ion-mediated CC-bond formation and cross-metathesis reactions, after which full deprotection led to the set of free 3-hydroxypiperidines.