Huiling Liu, Zongcheng Lieberzeit, T. Anthonsen
Sep 5, 2000
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0
Influential Citations
107
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Quality indicators
Journal
Molecules
Abstract
Abstract: Five derivatives of 2-imino-3-(4-arylthiazol-2-yl)-thiazolidin-4-ones and a series of their5-arylidene derivatives have been synthesized and tested for antifungal activity against seven agri-cultural fungi. 2-Imino-3-(2,4-dichloro-5-fluorophenylthiazol-2-yl)-4-thiazolidi-none and 2-imino-3-(2,4-dichlorophenylthiazol-2-yl)-4-thiazolidione, both of them new compounds, exhibited higherfungicidal effects than the other compounds prepared. Keywords: 2-imino-3-(4-arylthiazol-2-yl)-thiazolidin-4-ones, 5-arylidene derivatives, antifungalactivity. Introduction Thiazolidin-4-ones are important compounds due to their broad range of biological activities [1-7]. Over-views of their synthesis, properties, reactions and applications have been published[8,9]. 2-Imino-thiazolidin-4-ones have been found to have antifungal activity[10-12], and a convenient method for synthesis involves thereaction of 2-haloacetamides with potassium thiocyanate to produce 2-imino-thiazolidin-4-ones. The R- N -group at the 3-position of thiazolidin-4-ones may be varied to be alkyl, aryl, heterocyclic groups etc. It is alsowell known that the thiazole moiety can be important for significant biological activity [13-16].