Qiu Zhui-bai
2007
Citations
0
Influential Citations
2
Citations
Journal
Chinese Journal of Pharmaceuticals
Abstract
Gemcitabine hydrochloride was prepared from 2-deoxy-2,2-difluoro-D-erythro-pentofuranose-1- ketose-3,5-dibenzoate via LiAlH4 reduction and methylsulfonation to afford 2-deoxy-2,2-difluoro-D-ribofuranose-3,5- dibenzoate-1-methylsulfonate(3α/β), which was subjected to condensation with cytosine followed by deprotection, salt formation and separative crystallization in aqueous acetone with an overall yield of 14%.