Arindam Ghosh, A. Khan
Mar 19, 2014
Citations
0
Influential Citations
15
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The synthesis of dihydrochromeno[4,3-b]pyrazolo[4,3-e]pyridin-6(7H)-ones was achieved through one-pot three-component reaction from 4-hydroxycoumarin, aldehydes, and 3-amino-5-methyl-pyrazole in acetonitrile using 5 mol % TBATB as the catalyst under reflux condition. The product formation is through tandem Knoevenagel–Michael reaction followed by concomitant cyclization. Simple reaction procedure, shorter reaction time, good yields, avoidance of aqueous work-up, and column chromatographic separation are some of the salient features of the present protocol.