V. A. Glushkov, D. N. Babentsev, M. Dmitriev
Jan 1, 2021
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Influential Citations
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Journal
Chemistry of Heterocyclic Compounds
Abstract
4-Aryl-2-methylbutan-2-ols with methoxy or methylenedioxy substituents participate in the Graf–Ritter reaction with methyl thiocyanate in the presence of an acid (H 2 SO 4 , MeSO 3 H) forming 1-methylsulfanyl-2-benzazepines in low yields (11–35%), which undergo cyclization with benzhydrazide or hetarenecarboxylic acid hydrazides upon reflux in o -dichlorobenzene into the corresponding 3-phenyl- and 3-hetaryl-6,7-dihydro-5 H -1,2,4-triazolo[3,4- a ][2]benzazepines (45–74% yields).